Aminopyrimidine aminohydrolase

BE0001546ProteinBacillus subtilis (strain 168)tenA

Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. It is acted on by 2 drugs in DrugBank.

Gene name
tenA
UniProtKB entry
P25052Swiss-Prot
Residues / weight
236 residues · 27,416 Da
Also known as
3.5.99.2 · 4-amino-5-aminomethyl-2-methylpyrimidine hydrolase · Thiaminase II

Resolves to

Protein
UniProtP25052UniProt nameTENA_BACSU
Gene
NCBI Gene939807GenBank143729
Pharmacology
KEGGbsu:BSU11650
Structure
PDB1TO9PDB1TYHPDB1YAF
Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aminopyrimidine aminohydrolase, and which indications are they being tested in?

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