Aminopyrimidine aminohydrolase
Details
- Name
- Aminopyrimidine aminohydrolase
- Kind
- protein
- Synonyms
- 3.5.99.2
- 4-amino-5-aminomethyl-2-methylpyrimidine hydrolase
- Thiaminase II
- Gene Name
- tenA
- UniProtKB Entry
- P25052Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0019139|Aminopyrimidine aminohydrolase MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQDSYYLTHFAKVQSFGAA YAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKAFKPSPTAYSYTSHMYRSV LSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWIGTYGGDWFRQQVEEQINRFD ELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGWSDSAIKEVEECGASRHNG
- Number of residues
- 236
- Molecular Weight
- 27416.405
- Theoretical pI
- 4.93
- GO Classification
- Functionsthiaminase activityProcessesthiamine biosynthetic process / thiamine diphosphate biosynthetic process
- General Function
- Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4-amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP). To a lesser extent, is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity is unlikely to be physiologically relevant. Therefore, is involved in the regeneration of the thiamine pyrimidine from thiamine degraded products present in the environment, rather than in thiamine degradation.
- Specific Function
- thiaminase activity
- Pfam Domain Function
- TENA_THI-4 (PF03070)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019140|Aminopyrimidine aminohydrolase (tenA) GTGAAGTTTTCAGAAGAATGCCGCAGTGCAGCCGCAGAATGGTGGGAGGGGAGCTTTGTC CATCCGTTCGTTCAAGGAATCGGTGACGGAACGCTTCCGATTGACCGTTTTAAATACTAC GTACTTCAGGATTCCTATTATTTAACGCATTTTGCAAAGGTGCAGTCATTTGGTGCCGCT TATGCGAAGGATCTTTATACAACGGGGCGGATGGCAAGCCATGCCCAAGGTACATATGAG GCGGAAATGGCGCTTCATCGCGAGTTTGCCGAGCTGTTGGAAATCAGCGAGGAAGAGCGT AAGGCGTTTAAGCCGTCTCCTACGGCGTACTCTTATACATCCCATATGTACCGTTCGGTT TTGAGCGGGAATTTCGCAGAAATCTTAGCGGCCCTGCTGCCATGCTATTGGCTCTATTAC GAGGTTGGTGAGAAATTGCTGCATTGTGATCCGGGGCATCCAATTTATCAGAAGTGGATT GGCACATATGGCGGTGATTGGTTTAGACAACAGGTCGAGGAGCAAATCAACCGCTTTGAT GAGCTGGCGGAAAACAGCACGGAGGAAGTGCGTGCCAAGATGAAAGAGAATTTTGTCATC TCCAGCTACTATGAATATCAATTTTGGGGAATGGCCTATCGAAAAGAAGGCTGGTCTGAC AGCGCCATAAAAGAGGTGGAGGAATGTGGAGCTTCACGCCATAACGGATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P25052 UniProtKB Entry Name TENA_BACSU GenBank Protein ID 143729 GenBank Gene ID M73546 PDB ID(s) 1TO9, 1TYH, 1YAF, 1YAK, 2QCX KEGG ID bsu:BSU11650 NCBI Gene ID 939807 - General References
- Pang AS, Nathoo S, Wong SL: Cloning and characterization of a pair of novel genes that regulate production of extracellular enzymes in Bacillus subtilis. J Bacteriol. 1991 Jan;173(1):46-54. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Lee JM, Zhang S, Saha S, Santa Anna S, Jiang C, Perkins J: RNA expression analysis using an antisense Bacillus subtilis genome array. J Bacteriol. 2001 Dec;183(24):7371-80. [Article]
- Jenkins AH, Schyns G, Potot S, Sun G, Begley TP: A new thiamin salvage pathway. Nat Chem Biol. 2007 Aug;3(8):492-7. Epub 2007 Jul 8. [Article]
- Toms AV, Haas AL, Park JH, Begley TP, Ealick SE: Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 2005 Feb 22;44(7):2319-29. [Article]
- Jenkins AL, Zhang Y, Ealick SE, Begley TP: Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. Bioorg Chem. 2008 Feb;36(1):29-32. Epub 2007 Dec 3. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 4-Amino-5-Hydroxymethyl-2-Methylpyrimidine experimental unknown target Details