Dihydrofolate reductase

BE0001555ProteinPneumocystis carinii

Key enzyme in folate metabolism. It is acted on by 7 drugs in DrugBank.

UniProtKB entry
P16184Swiss-Prot
Residues / weight
206 residues · 23,883 Da
Also known as
1.5.1.3

Resolves to

Protein
UniProtP16184UniProt nameDYR_PNECA
Gene
GenBank169408
Structure
PDB1CD2PDB1DAJPDB1DYR
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
21+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Dihydrofolate reductase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In