Leukotriene A-4 hydrolase

BE0001680ProteinHumansLTA4H

Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. It is acted on by 25 drugs in DrugBank.

Gene name
LTA4H
UniProtKB entry
P09960Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
611 residues · 69,285 Da
Also known as
3.3.2.6 · Leukotriene A(4) hydrolase · LTA-4 hydrolase · LTA4 · Tripeptide aminopeptidase LTA4H

Resolves to

Protein
UniProtP09960UniProt nameLKHA4_HUMAN
Gene
HGNCHGNC:6710NCBI Gene4048GenBank976396GeneCardsLTA4H
Pharmacology
IUPHAR/GtoPdb1395KEGGhsa:4048
Structure
PDB1GW6PDB1H19PDB1HS6
Drugs

What you can answer from here — as of September 07, 2019

25DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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98+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Leukotriene A-4 hydrolase, how selective are they, and which programs against it are still in active trials?

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