Fructose-bisphosphate aldolase A

BE0001683ProteinHumansALDOA

Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). It is acted on by 11 drugs in DrugBank.

Gene name
ALDOA
UniProtKB entry
P04075Swiss-Prot
Cellular location
Cytoplasm, myofibril, sarcomere, I band
Residues / weight
364 residues · 39,420 Da
Also known as
4.1.2.13 · ALDA · Lung cancer antigen NY-LU-1 · Muscle-type aldolase

Resolves to

Protein
UniProtP04075UniProt nameALDOA_HUMAN
Gene
HGNCHGNC:414NCBI Gene226GenBank178351GeneCardsALDOA
Pharmacology
KEGGhsa:226
Structure
PDB1ALDPDB2ALDPDB4ALD
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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49+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fructose-bisphosphate aldolase A, how selective are they, and which programs against it are still in active trials?

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