2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Details
- Name
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
- Kind
- protein
- Synonyms
- 2.7.7.60
- 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
- MCT
- MEP cytidylyltransferase
- Gene Name
- ispD
- UniProtKB Entry
- Q9X1B3Swiss-Prot
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- NCBI Taxonomy ID
- 243274
- Amino acid sequence
>lcl|BSEQ0011319|2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MNVAILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVV EKRVFHEKVLGIVEGGDTRSQSVRSALEFLEKFSPSYVLVHDSARPFLRKKHVSEVLRRA RETGAATLALKNSDALVRVENDRIEYIPRKGVYRILTPQAFSYEILKKAHENGGEWADDT EPVQKLGVKIALVEGDPLCFKVTFKEDLELARIIAREWERIP
- Number of residues
- 222
- Molecular Weight
- 25370.055
- Theoretical pI
- 7.66
- GO Classification
- Functions2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activityProcessesisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway / terpenoid biosynthetic process
- General Function
- Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
- Specific Function
- 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
- Pfam Domain Function
- IspD (PF01128)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011320|2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD) ATGAACGTAGCGATTCTCCTTGCAGCGGGAAAAGGTGAAAGAATGTCTGAAAACGTTCCA AAACAGTTCCTCGAGATAGAGGGAAGGATGCTTTTCGAGTATCCGCTTTCCACGTTTTTG AAAAGTGAAGCGATAGATGGTGTTGTGATAGTGACACGAAGAGAGTGGTTCGAAGTTGTA GAGAAAAGAGTGTTCCACGAAAAAGTACTCGGAATTGTCGAGGGTGGAGATACACGAAGC CAGAGTGTGAGAAGCGCCCTCGAATTTCTTGAAAAGTTCTCTCCCTCTTACGTTCTCGTA CACGACTCAGCACGGCCGTTTCTGAGGAAGAAACACGTGTCGGAGGTTCTCAGAAGAGCC CGCGAAACGGGAGCGGCAACCCTCGCGTTGAAGAATTCCGACGCGCTCGTAAGAGTTGAG AACGACAGAATAGAATACATCCCAAGAAAAGGAGTGTACAGAATTCTTACACCGCAGGCT TTTTCTTACGAGATTTTGAAAAAGGCCCATGAAAATGGTGGCGAATGGGCAGACGACACG GAACCTGTTCAAAAGCTCGGAGTGAAAATAGCCTTGGTCGAGGGAGATCCTTTGTGTTTC AAAGTGACGTTTAAAGAAGACCTGGAACTGGCGAGAATCATCGCCAGAGAATGGGAGAGG ATACCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X1B3 UniProtKB Entry Name ISPD_THEMA GenBank Protein ID 4981955 GenBank Gene ID AE000512 PDB ID(s) 1VPA KEGG ID tma:TM1393 NCBI Gene ID 898083 - General References
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Cytidine-5'-Triphosphate experimental unknown target Details