Aconitate hydratase B

BE0001951ProteinEscherichia coli (strain K12)acnB

Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2-methylcitrate cycle I (propionate degradation route). It is acted on by 1 drug in DrugBank.

Gene name
acnB
UniProtKB entry
P36683Swiss-Prot
Residues / weight
865 residues · 93,497 Da
Also known as
(2R,3S)-2-methylisocitrate dehydratase · (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase · 2-methyl-cis-aconitate hydratase · 4.2.1.3 · ACN

Resolves to

Protein
UniProtP36683UniProt nameACNB_ECOLI
Gene
NCBI Gene944864GenBank2367097
Pharmacology
KEGGecj:JW0114
Structure
PDB1L5J
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aconitate hydratase B, and which indications are they being tested in?

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