2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]

BE0001961ProteinEscherichia coli (strain K12)fadH

Functions as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids with double bonds at even carbon positions. It is acted on by 4 drugs in DrugBank.

Gene name
fadH
UniProtKB entry
P42593Swiss-Prot
Residues / weight
672 residues · 72,678 Da
Also known as
1.3.1.34 · 2,4-dienoyl coenzyme A reductase · 2,4-dienoyl-CoA reductase [NADPH] · 2,4-dienoyl-coenzyme A reductase [NADPH] · DCR

Resolves to

Protein
UniProtP42593UniProt nameFADH_ECOLI
Gene
NCBI Gene947594GenBank2584857
Pharmacology
KEGGecj:JW3052
Structure
PDB1PS9
Drugs

What you can answer from here — as of May 03, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing], how selective are they, and which programs against it are still in active trials?

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