Tyrosine--tRNA ligase

BE0001962ProteinThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)tyrS

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). It is acted on by 1 drug in DrugBank.

Gene name
tyrS
UniProtKB entry
P83453Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
432 residues · 48,718 Da
Also known as
6.1.1.1 · Tyrosyl-tRNA synthetase · TyrRS

Resolves to

Protein
UniProtP83453UniProt nameSYY_THET2
Gene
GenBank46196960
Pharmacology
KEGGtth:TTC1033
Structure
PDB1H3EPDB1H3F
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tyrosine--tRNA ligase, and which indications are they being tested in?

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