Peptidoglycan-N-acetylmuramic acid deacetylase PdaA

BE0001989ProteinBacillus subtilis (strain 168)pdaA

Catalyzes the deacetylation of N-acetylmuramic acid (MurNAc) residues in glycan strands of peptidoglycan, leading to the formation of muramic delta-lactam residues in spore cortex, after transpeptidation of deacetylated muramic acid residues. It is acted on by 1 drug in DrugBank.

Gene name
pdaA
UniProtKB entry
O34928Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
263 residues · 30,069 Da
Also known as
3.5.1.- · Muramic-delta-lactam synthase · Peptidoglycan MurNAc deacetylase · yfjS

Resolves to

Protein
UniProtO34928UniProt namePDAA_BACSU
Gene
NCBI Gene936136GenBank2626811
Pharmacology
KEGGbsu:BSU07980
Structure
PDB1NY1PDB1W17PDB1W1A
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Peptidoglycan-N-acetylmuramic acid deacetylase PdaA, and which indications are they being tested in?

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