Fructose-bisphosphate aldolase class 2

BE0002021ProteinEscherichia coli (strain K12)fbaA

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (PubMed:10712619). It is acted on by 1 drug in DrugBank.

Gene name
fbaA
UniProtKB entry
P0AB71Swiss-Prot
Residues / weight
359 residues · 39,147 Da
Also known as
4.1.2.13 · fba · FBP aldolase · fda · Fructose-1,6-bisphosphate aldolase

Resolves to

Protein
UniProtP0AB71UniProt nameALF_ECOLI
Gene
NCBI Gene947415
Pharmacology
KEGGecj:JW2892
Structure
PDB1B57PDB1DOSPDB1GYN
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Fructose-bisphosphate aldolase class 2, and which indications are they being tested in?

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