Phospholipase A1

BE0002041ProteinEscherichia coli (strain K12)pldA

Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. It is acted on by 1 drug in DrugBank.

Gene name
pldA
UniProtKB entry
P0A921Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
289 residues · 33,163 Da
Also known as
3.1.1.32 · Detergent-resistant phospholipase A · DR-phospholipase A · OM PLA · OMPLA

Resolves to

Protein
UniProtP0A921UniProt namePA1_ECOLI
Gene
NCBI Gene948307GenBank757840
Pharmacology
KEGGecj:JW3794
Structure
PDB1FW2PDB1FW3PDB1ILD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phospholipase A1, and which indications are they being tested in?

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