D-alanyl-D-alanine carboxypeptidase DacA

BE0002063ProteinEscherichia coli (strain K12)dacA

Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. It is acted on by 6 drugs in DrugBank.

Gene name
dacA
UniProtKB entry
P0AEB2Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
403 residues · 44,444 Da
Also known as
3.4.16.4 · Beta-lactamase · DD-carboxypeptidase · PBP-5 · Penicillin-binding protein 5

Resolves to

Protein
UniProtP0AEB2UniProt nameDACA_ECOLI
Gene
NCBI Gene945222
Pharmacology
KEGGecj:JW0627
Structure
PDB1HD8PDB1NJ4PDB1NZO
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on D-alanyl-D-alanine carboxypeptidase DacA, how selective are they, and which programs against it are still in active trials?

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