Fibrinogen beta chain

BE0002091ProteinHumansFGB

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. It is acted on by 7 drugs in DrugBank.

Gene name
FGB
UniProtKB entry
P02675Swiss-Prot
Cellular location
Secreted
Residues / weight
491 residues · 55,928 Da

Resolves to

Protein
UniProtP02675UniProt nameFIBB_HUMAN
Gene
HGNCHGNC:3662NCBI Gene2244GenBank182430GeneCardsFGB
Pharmacology
KEGGhsa:2244
Structure
PDB1FZAPDB1FZBPDB1FZC
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fibrinogen beta chain, how selective are they, and which programs against it are still in active trials?

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