Potassium voltage-gated channel subfamily KQT member 3

BE0002398ProteinHumansKCNQ3

Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:16319223, PubMed:27564677, PubMed:28793216, PubMed:9872318). It is acted on by 9 drugs in DrugBank.

Gene name
KCNQ3
UniProtKB entry
O43525Swiss-Prot
Cellular location
Cell membrane
Residues / weight
872 residues · 96,742 Da
Also known as
KQT-like 3 · Potassium channel subunit alpha KvLQT3 · Voltage-gated potassium channel subunit Kv7.3

Resolves to

Protein
UniProtO43525UniProt nameKCNQ3_HUMAN
Gene
HGNCHGNC:6297NCBI Gene3786GeneCardsKCNQ3
Pharmacology
IUPHAR/GtoPdb562KEGGhsa:3786
Structure
PDB5J03
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
38+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Potassium voltage-gated channel subfamily KQT member 3, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In