Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

BE0002407ProteinHumansPIK3CB

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides (PubMed:15135396). It is acted on by 12 drugs in DrugBank.

Gene name
PIK3CB
UniProtKB entry
P42338Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,070 residues · 122,761 Da
Also known as
2.7.1.153 · p110beta · Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta · PI3-kinase subunit beta · PI3K-beta

Resolves to

Protein
UniProtP42338UniProt namePK3CB_HUMAN
Gene
HGNCHGNC:8976NCBI Gene5291GeneCardsPIK3CB
Pharmacology
IUPHAR/GtoPdb2154KEGGhsa:5291
Drugs

What you can answer from here — as of September 07, 2019

12DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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25GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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46+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, how selective are they, and which programs against it are still in active trials?

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