AZD-8186

DB15029InvestigationalSmall molecule

AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be...

Mechanism: Pharmacologically active on Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Curator reviewed
Formula / weight: C₂₄H₂₅F₂N₃O₄ · 457.478 g/mol (avg)
Code names: AZD-8186

Resolves to

Compound

UNIIAIQ4OWD0RACAS1627494-13-6ChEMBLCHEMBL3408248

Structure

InChIKeyLMJFJIDLEAWOQJ-CQSZACIVSA-NSMILESC[C@@H](NC1=CC(F)=CC(F)=C1)C1=CC(=CC2=C1OC(=CC2=O)N1CCOCC1)C(=O)N(C)C

Targets

O00329PIK3CDP42338PIK3CBP48736PIK3CG

What you can answer from here — as of June 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

6+ReferencesStructured and connected to the statements they support

Which drugs share a target with AZD-8186, and which of those have an active Phase 3 trial?

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