Plasma kallikrein

BE0002440ProteinHumansKLKB1

Participates in the surface-dependent activation of blood coagulation. It is acted on by 15 drugs in DrugBank.

Gene name
KLKB1
UniProtKB entry
P03952Swiss-Prot
Cellular location
Secreted
Residues / weight
638 residues · 71,342 Da
Also known as
3.4.21.34 · Fletcher factor · Kininogenin · KLK3 · PKK

Resolves to

Protein
UniProtP03952UniProt nameKLKB1_HUMAN
Gene
HGNCHGNC:6371NCBI Gene3818GeneCardsKLKB1
Pharmacology
IUPHAR/GtoPdb2379KEGGhsa:3818
Structure
PDB10KZPDB10LRPDB10MV
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Plasma kallikrein, how selective are they, and which programs against it are still in active trials?

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