tRNA (cytosine(38)-C(5))-methyltransferase

BE0002517ProteinHumansTRDMT1

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). It is acted on by 3 drugs in DrugBank.

Gene name
TRDMT1
UniProtKB entry
O14717Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
391 residues · 44,596 Da
Also known as
2.1.1.204 · DNA (cytosine-5)-methyltransferase-like protein 2 · DNA methyltransferase homolog HsaIIP · DNA MTase homolog HsaIIP · DNMT2

Resolves to

Protein
UniProtO14717UniProt nameTRDMT_HUMAN
Gene
HGNCHGNC:2977NCBI Gene1787GeneCardsTRDMT1
Pharmacology
KEGGhsa:1787
Structure
PDB1G55PDB9HGM
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on tRNA (cytosine(38)-C(5))-methyltransferase, how selective are they, and which programs against it are still in active trials?

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