Protein-L-isoaspartate O-methyltransferase

BE0002532ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)pcm

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It is acted on by 1 drug in DrugBank.

Gene name
pcm
UniProtKB entry
Q56308Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
317 residues · 36,400 Da
Also known as
2.1.1.77 · L-isoaspartyl protein carboxyl methyltransferase · PIMT · Protein L-isoaspartyl methyltransferase · Protein-beta-aspartate methyltransferase

Resolves to

Protein
UniProtQ56308UniProt namePIMT_THEMA
Gene
NCBI Gene898371
Pharmacology
KEGGtma:TM0704
Structure
PDB1DL5
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein-L-isoaspartate O-methyltransferase, and which indications are they being tested in?

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