Sulfotransferase 1B1

BE0002561ProteinHumansSULT1B1

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139,... It is acted on by 5 drugs in DrugBank.

Gene name
SULT1B1
UniProtKB entry
O43704Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
296 residues · 34,899 Da
Also known as
2.8.2.1 · ST1B1 · ST1B2 · Sulfotransferase 1B2 · Sulfotransferase family cytosolic 1B member 1

Resolves to

Protein
UniProtO43704UniProt nameST1B1_HUMAN
Gene
HGNCHGNC:17845NCBI Gene27284GeneCardsSULT1B1
Pharmacology
KEGGhsa:27284
Structure
PDB2Z5FPDB3CKL
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sulfotransferase 1B1, how selective are they, and which programs against it are still in active trials?

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