Sulfotransferase 1B1

Details

Name
Sulfotransferase 1B1
Kind
protein
Synonyms
  • 2.8.2.1
  • ST1B1
  • ST1B2
  • Sulfotransferase 1B2
  • Sulfotransferase family cytosolic 1B member 1
  • SULT1B2
  • Thyroid hormone sulfotransferase
Gene Name
SULT1B1
UniProtKB Entry
O43704Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0011826|Sulfotransferase 1B1
MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDM
ILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFW
ENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNW
WKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVN
YTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
Number of residues
296
Molecular Weight
34898.955
Theoretical pI
7.07
GO Classification
Processes
biogenic amine metabolic process / ethanol catabolic process
Components
cytoplasm
General Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440)
Specific Function
aryl sulfotransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011827|Sulfotransferase family cytosolic 1B member 1 (SULT1B1)
ATGCTTTCCCCAAAAGATATTCTGCGAAAAGATCTGAAGTTGGTCCATGGTTATCCCATG
ACCTGTGCTTTTGCAAGCAACTGGGAAAAAATTGAACAGTTCCATAGCAGACCAGATGAC
ATTGTGATAGCCACTTATCCTAAATCAGGTACTACTTGGGTTAGTGAAATTATAGACATG
ATTCTAAATGATGGAGATATTGAAAAATGTAAGCGAGGTTTTATTACTGAAAAAGTTCCA
ATGTTGGAAATGACTCTCCCTGGATTAAGAACATCAGGTATAGAACAATTGGAGAAGAAT
CCATCACCCCGGATTGTGAAAACACATCTACCGACTGATCTTCTTCCTAAATCTTTCTGG
GAAAACAATTGCAAGATGATTTATCTGGCTCGTAATGCCAAGGATGTTTCAGTCTCATAT
TACCATTTTGACTTAATGAATAATTTACAGCCTTTTCCTGGTACCTGGGAAGAATATCTG
GAGAAATTCTTAACTGGAAAAGTGGCCTATGGTTCCTGGTTTACTCATGTTAAAAACTGG
TGGAAGAAAAAGGAAGAACACCCAATACTTTTTTTGTACTATGAAGATATGAAAGAGAAT
CCAAAGGAGGAAATCAAGAAGATCATTAGATTTCTAGAGAAGAACCTGAATGATGAGATC
TTGGATAGGATCATCCATCACACCTCATTTGAAGTGATGAAGGACAATCCTTTGGTAAAT
TATACACATCTACCAACTACAGTGATGGATCATAGCAAATCCCCTTTTATGCGTAAAGGG
ACGGCTGGTGACTGGAAGAATTACTTCACCGTGGCCCAAAATGAGAAATTTGATGCTATT
TATGAGACAGAAATGTCCAAAACTGCACTTCAATTCCGCACAGAGATTTAA
Chromosome Location
4
Locus
4q13.3
External Identifiers
ResourceLink
UniProtKB IDO43704
UniProtKB Entry NameST1B1_HUMAN
GenBank Gene IDD89479
GeneCard IDSULT1B1
GenAtlas IDSULT1B1
HGNC IDHGNC:17845
PDB ID(s)2Z5F, 3CKL
KEGG IDhsa:27284
NCBI Gene ID27284
General References
  1. Fujita K, Nagata K, Ozawa S, Sasano H, Yamazoe Y: Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. J Biochem. 1997 Nov;122(5):1052-61. [Article]
  2. Wang J, Falany JL, Falany CN: Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. Mol Pharmacol. 1998 Feb;53(2):274-82. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Dombrovski L, Dong A, Bochkarev A, Plotnikov AN: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). Proteins. 2006 Sep 1;64(4):1091-4. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Adenosine 3',5'-diphosphateexperimentalunknowntargetDetails
Curcumin sulfateexperimentalunknownenzymesubstrateDetails
Thyroid, porcineapprovedunknownenzymesubstrateDetails
Apomorphineapproved, investigationalunknownenzymesubstrateDetails