Diiodohydroxyquinoline

Identification

Brand Names
Alcortin, Alcortin A, Aloquin, Dermazene, Vytone
Generic Name
Diiodohydroxyquinoline
DrugBank Accession Number
DB09115
Background

Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 396.954
Monoisotopic: 396.84605
Chemical Formula
C9H5I2NO
Synonyms
  • Diiodohydroxyquin
  • Diiodohydroxyquinoline
  • Iodoquinol
  • Ioquin
External IDs
  • NSC-8704
  • SS-578

Pharmacology

Indication

Used in the treatment of amoebiasis.

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Our Blackbox Warnings cover Risks, Contraindications, and Adverse Effects
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Pharmacodynamics

Not Available

Mechanism of action

Unknown.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
  • Take after a meal. This may reduce gastrointestinal irritation.

Products

Products
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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Diodoquin Tab 210mgTabletOralGlenwood Inc.1992-12-312015-06-18Canada flag
Diodoquin Tab 650mgTabletOralGlenwood Inc.1992-12-312014-07-30Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Ovoquinol ConesDiiodohydroxyquinoline (75 mg) + Sulfadiazine (400 mg) + Undecylenic acid (50 mg)SuppositoryVaginalLab Nadeau LtÉe, Division Of Technilab Inc.1963-12-311999-09-28Canada flag
Ovoquinol Crm VaginaleDiiodohydroxyquinoline (2 %) + Sulfadiazine (8 %) + Undecylenic acid (1 %)CreamVaginalLab Nadeau LtÉe, Division Of Technilab Inc.1980-12-311999-09-28Canada flag
ไกโอเน็ปDiiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU)TabletVaginalบริษัท โรงงานผลิตเวชภัณฑ์ชินต้าเทรดดิ้ง (1971) จำกัด จำกัด1988-02-12Not applicableThailand flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AlcortinDiiodohydroxyquinoline (1 g/100g) + Hydrocortisone (2 g/100g)GelTopicalPrimus Pharmaceuticals2003-07-25Not applicableUS flag
Alcortin ADiiodohydroxyquinoline (10 mg/1g) + Aloe Vera Leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalPrimus Pharmaceuticals2010-01-01Not applicableUS flag
Alcortin ADiiodohydroxyquinoline (10 mg/1g) + Aloe Vera Leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalNovum Pharma, Llc2015-03-01Not applicableUS flag
AloquinDiiodohydroxyquinoline (12.5 mg/1g) + Aloe Vera Leaf (10 mg/1g)GelTopicalNovum Pharma, Llc2015-03-012018-06-01US flag
AloquinDiiodohydroxyquinoline (12.5 mg/1g) + Aloe Vera Leaf (10 mg/1g)GelTopicalPrimus Pharmaceuticals2009-07-06Not applicableUS flag
DermazeneDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone (10 mg/1g)CreamTopicalStratus Pharmaceuticals2001-06-11Not applicableUS flag
Hydro-IodoquinolDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (20 mg/1g)GelTopicalSeton Pharmaceuticals2010-06-102010-10-02US flag
Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2%Diiodohydroxyquinoline (1 g/100g) + Hydrocortisone (2.5 g/100g) + Ketoconazole (2 g/100g)CreamTopicalSincerus Florida, LLC2019-05-17Not applicableUS flag
Hydrocortisone Acetate, IodoquinolDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (19 mg/1g)CreamTopicalBowyn Labs, Llc2011-07-29Not applicableUS flag
Hydrocortisone IodoquinolDiiodohydroxyquinoline (10 mg/1g) + Hydrocortisone (10 mg/1g)CreamTopicalPhysicians Total Care, Inc.2004-05-192013-01-15US flag

Categories

ATC Codes
G01AC01 — Diiodohydroxyquinoline
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as haloquinolines. These are compounds containing a quinoline moiety, which is substituted at one or more ring positions by n halogen atom.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Quinolines and derivatives
Sub Class
Haloquinolines
Direct Parent
Haloquinolines
Alternative Parents
8-hydroxyquinolines / P-iodophenols / O-iodophenols / Pyridines and derivatives / Aryl iodides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds
show 2 more
Substituents
2-iodophenol / 4-iodophenol / 8-hydroxyquinoline / Aromatic heteropolycyclic compound / Aryl halide / Aryl iodide / Azacycle / Benzenoid / Haloquinoline / Heteroaromatic compound
show 9 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
quinolines (CHEBI:5950)
Affected organisms
Not Available

Chemical Identifiers

UNII
63W7IE88K8
CAS number
83-73-8
InChI Key
UXZFQZANDVDGMM-UHFFFAOYSA-N
InChI
InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
IUPAC Name
5,7-diiodoquinolin-8-ol
SMILES
OC1=C2N=CC=CC2=C(I)C=C1I

References

General References
Not Available
KEGG Drug
D00581
KEGG Compound
C07636
PubChem Compound
3728
PubChem Substance
310265032
ChemSpider
3597
BindingDB
66035
RxNav
3435
ChEBI
5950
ChEMBL
CHEMBL86754
ZINC
ZINC000003830942
Drugs.com
Drugs.com Drug Page
Wikipedia
Diiodohydroxyquinoline

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GelTopical
TabletOral
CreamTopical
SuppositoryVaginal
CreamVaginal
TabletVaginal
TabletVaginal
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0815 mg/mLALOGPS
logP3.93ALOGPS
logP3.69ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)7.39ChemAxon
pKa (Strongest Basic)3.34ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area33.12 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity68.69 m3·mol-1ChemAxon
Polarizability25.9 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on September 22, 2015 17:14 / Updated on February 21, 2021 18:52