Identification
- Brand Names
- Alcortin, Alcortin A, Aloquin, Dermazene, Vytone
- Generic Name
- Diiodohydroxyquinoline
- DrugBank Accession Number
- DB09115
- Background
Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Diiodohydroxyquinoline (DB09115)
- Weight
- Average: 396.954
Monoisotopic: 396.84605 - Chemical Formula
- C9H5I2NO
- Synonyms
- Diiodohydroxyquin
- Diiodohydroxyquinoline
- Iodoquinol
- Ioquin
- External IDs
- NSC-8704
- SS-578
Pharmacology
- Indication
Used in the treatment of amoebiasis.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
Unknown.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Take after a meal. This may reduce gastrointestinal irritation.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Diodoquin Tab 210mg Tablet 210 mg Oral Glenwood Inc. 1992-12-31 2015-06-18 Canada 
Diodoquin Tab 650mg Tablet 650 mg Oral Glenwood Inc. 1992-12-31 2014-07-30 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image GYNECON - T Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท คอนติเนนเติล-ฟาร์ม จำกัด จำกัด 2005-03-10 Not applicable Thailand 
Ovoquinol Cones Diiodohydroxyquinoline (75 mg / sup) + Sulfadiazine (400 mg / sup) + Undecylenic acid (50 mg / sup) Suppository Vaginal Lab Nadeau LtÉe, Division Of Technilab Inc. 1963-12-31 1999-09-28 Canada Ovoquinol Crm Vaginale Diiodohydroxyquinoline (2 %) + Sulfadiazine (8 %) + Undecylenic acid (1 %) Cream Vaginal Lab Nadeau LtÉe, Division Of Technilab Inc. 1980-12-31 1999-09-28 Canada นากีน่า Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท เอช.เค.ฟาร์มาซูติคอล จำกัด 2015-12-03 Not applicable Thailand นิสติน Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท โปลิฟาร์ม จำกัด จำกัด 1987-08-24 Not applicable Thailand มาโนไกเน Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท โรงงานเภสัชกรรมแหลมทองการแพทย์ จำกัด จำกัด 1991-02-11 Not applicable Thailand วี.จี. เมด ( ชนิดเม็ด ) Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท ที. แมน ฟาร์มา จำกัด 1987-10-06 Not applicable Thailand แบคซีลา เม็ด Diiodohydroxyquinoline (250 mg) + Furazolidone (50 mg) + Neomycin sulfate (50 mg) + Succinylsulfathiazole (250 mg) Tablet บริษัท ไบร์วู๊ดฟาร์มาซูติคอล จำกัด 1986-03-07 2020-07-19 Thailand ไกเนติน Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท ฟาร์สเป็ค จำกัด จำกัด 1990-08-16 Not applicable Thailand ไกโอเน็ป Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท โรงงานผลิตเวชภัณฑ์ชินต้าเทรดดิ้ง (1971) จำกัด จำกัด 1988-02-12 Not applicable Thailand - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Alcortin Diiodohydroxyquinoline (1 g/100g) + Hydrocortisone (2 g/100g) Gel Topical Primus Pharmaceuticals 2003-07-25 Not applicable US 
Alcortin A Diiodohydroxyquinoline (10 mg/1g) + Aloe vera leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g) Gel Topical Primus Pharmaceuticals 2010-01-01 Not applicable US Alcortin A Diiodohydroxyquinoline (10 mg/1g) + Aloe vera leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g) Gel Topical Novum Pharma, Llc 2015-03-01 2021-08-31 US Aloquin Diiodohydroxyquinoline (12.5 mg/1g) + Aloe vera leaf (10 mg/1g) Gel Topical Novum Pharma, Llc 2015-03-01 2018-06-01 US Aloquin Diiodohydroxyquinoline (12.5 mg/1g) + Aloe vera leaf (10 mg/1g) Gel Topical Primus Pharmaceuticals 2009-07-06 Not applicable US Corti-Sav Diiodohydroxyquinoline (10 mg/1g) + Hydrocortisone (10 mg/1g) Cream Topical Prime Labs LLC DBA Quality CDMO 2020-06-01 Not applicable US Corti-Sav Diiodohydroxyquinoline (10 mg/1g) + Hydrocortisone (10 mg/1g) Cream Topical Lifsa Drugs Llc 2021-07-15 Not applicable US Dermazene Diiodohydroxyquinoline (10 mg/1g) + Hydrocortisone (10 mg/1g) Cream Topical Stratus Pharmaceuticals 2001-06-11 Not applicable US Hydro-Iodoquinol Diiodohydroxyquinoline (10 mg/1g) + Hydrocortisone acetate (20 mg/1g) Gel Topical Seton Pharmaceuticals 2010-06-10 2010-10-02 US Hydrocortisone 2.5% / Iodoquinol 1% / Ketoconazole 2% Diiodohydroxyquinoline (1 g/100g) + Hydrocortisone (2.5 g/100g) + Ketoconazole (2 g/100g) Cream Topical Sincerus Florida, LLC 2019-05-17 Not applicable US
Categories
- ATC Codes
- G01AC01 — Diiodohydroxyquinoline
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as haloquinolines. These are compounds containing a quinoline moiety, which is substituted at one or more ring positions by n halogen atom.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Quinolines and derivatives
- Sub Class
- Haloquinolines
- Direct Parent
- Haloquinolines
- Alternative Parents
- 8-hydroxyquinolines / P-iodophenols / O-iodophenols / Pyridines and derivatives / Aryl iodides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds show 2 more
- Substituents
- 2-iodophenol / 4-iodophenol / 8-hydroxyquinoline / Aromatic heteropolycyclic compound / Aryl halide / Aryl iodide / Azacycle / Benzenoid / Haloquinoline / Heteroaromatic compound show 9 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- quinolines (CHEBI:5950)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 63W7IE88K8
- CAS number
- 83-73-8
- InChI Key
- UXZFQZANDVDGMM-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
- IUPAC Name
- 5,7-diiodoquinolin-8-ol
- SMILES
- OC1=C2N=CC=CC2=C(I)C=C1I
References
- General References
- Not Available
- External Links
- KEGG Drug
- D00581
- KEGG Compound
- C07636
- PubChem Compound
- 3728
- PubChem Substance
- 310265032
- ChemSpider
- 3597
- BindingDB
- 66035
- 3435
- ChEBI
- 5950
- ChEMBL
- CHEMBL86754
- ZINC
- ZINC000003830942
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Diiodohydroxyquinoline
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Topical Tablet Oral 210 mg Tablet Oral 650 mg Tablet Oral Cream Topical Suppository Vaginal Cream Vaginal Tablet Vaginal 100 mg Tablet Vaginal Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0815 mg/mL ALOGPS logP 3.93 ALOGPS logP 3.69 ChemAxon logS -3.7 ALOGPS pKa (Strongest Acidic) 7.39 ChemAxon pKa (Strongest Basic) 3.34 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 2 ChemAxon Hydrogen Donor Count 1 ChemAxon Polar Surface Area 33.12 Å2 ChemAxon Rotatable Bond Count 0 ChemAxon Refractivity 68.69 m3·mol-1 ChemAxon Polarizability 25.9 Å3 ChemAxon Number of Rings 2 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Drug created at September 22, 2015 17:14 / Updated at February 21, 2021 18:52