Diiodohydroxyquinoline
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Explore a selection of our essential drug information below, or:
Identification
- Brand Names
- Alcortin, Alcortin A, Aloquin, Dermazene, Vytone
- Generic Name
- Diiodohydroxyquinoline
- DrugBank Accession Number
- DB09115
- Background
Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 396.954
Monoisotopic: 396.84605 - Chemical Formula
- C9H5I2NO
- Synonyms
- Diiodohydroxyquin
- Diiodohydroxyquinoline
- Iodoquinol
- Ioquin
- External IDs
- NSC-8704
- SS-578
Pharmacology
- Indication
Used in the treatment of amoebiasis.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Dysentery Combination Product in combination with: Neomycin (DB00994), Phthalylsulfathiazole (DB13248), Furazolidone (DB00614) •••••••••••• •••••• Used in combination to treat Enteritis Combination Product in combination with: Furazolidone (DB00614), Neomycin (DB00994), Phthalylsulfathiazole (DB13248) •••••••••••• •••••• Used in combination to treat Gastrointestinal infections Combination Product in combination with: Neomycin (DB00994), Phthalylsulfathiazole (DB13248), Furazolidone (DB00614) •••••••••••• •••••• Used in combination to treat Infectious diarrhea Combination Product in combination with: Neomycin (DB00994), Phthalylsulfathiazole (DB13248), Furazolidone (DB00614) •••••••••••• •••••• Used in combination to treat Trichomonas vaginalis infection Combination Product in combination with: Benzalkonium (DB11105), Nystatin (DB00646) •••••••••••• •••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
Unknown.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Take after a meal. This may reduce gastrointestinal irritation.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Diodoquin Tab 210mg Tablet 210 mg Oral Glenwood Inc. 1992-12-31 2015-06-18 Canada Diodoquin Tab 650mg Tablet 650 mg Oral Glenwood Inc. 1992-12-31 2014-07-30 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image GYNECON - T Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท คอนติเนนเติล-ฟาร์ม จำกัด จำกัด 2005-03-10 Not applicable Thailand Ovoquinol Cones Diiodohydroxyquinoline (75 mg / sup) + Sulfadiazine (400 mg / sup) + Undecylenic acid (50 mg / sup) Suppository Vaginal Lab Nadeau LtÉe, Division Of Technilab Inc. 1963-12-31 1999-09-28 Canada Ovoquinol Crm Vaginale Diiodohydroxyquinoline (2 %) + Sulfadiazine (8 %) + Undecylenic acid (1 %) Cream Vaginal Lab Nadeau LtÉe, Division Of Technilab Inc. 1980-12-31 1999-09-28 Canada นากีน่า Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท เอช.เค.ฟาร์มาซูติคอล จำกัด 2015-12-03 Not applicable Thailand นิสติน Diiodohydroxyquinoline (100 MG) + Benzalkonium (7 MG) + Nystatin (100000 IU) Tablet Vaginal บริษัท โปลิฟาร์ม จำกัด จำกัด 1987-08-24 Not applicable Thailand - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Alcortin Diiodohydroxyquinoline (1 g/100g) + Hydrocortisone (2 g/100g) Gel Topical Primus Pharmaceuticals 2003-07-25 Not applicable US Alcortin A Diiodohydroxyquinoline (10 mg/1g) + Aloe vera leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g) Gel Topical Novum Pharma, Llc 2015-03-01 2021-08-31 US Alcortin A Diiodohydroxyquinoline (10 mg/1g) + Aloe vera leaf (10 mg/1g) + Hydrocortisone acetate (20 mg/1g) Gel Topical Primus Pharmaceuticals 2010-01-01 Not applicable US Aloquin Diiodohydroxyquinoline (12.5 mg/1g) + Aloe vera leaf (10 mg/1g) Gel Topical Primus Pharmaceuticals 2009-07-06 Not applicable US Aloquin Diiodohydroxyquinoline (12.5 mg/1g) + Aloe vera leaf (10 mg/1g) Gel Topical Novum Pharma, Llc 2015-03-01 2018-06-01 US
Categories
- ATC Codes
- G01AC01 — Diiodohydroxyquinoline
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as haloquinolines. These are compounds containing a quinoline moiety, which is substituted at one or more ring positions by n halogen atom.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Quinolines and derivatives
- Sub Class
- Haloquinolines
- Direct Parent
- Haloquinolines
- Alternative Parents
- 8-hydroxyquinolines / P-iodophenols / O-iodophenols / Pyridines and derivatives / Aryl iodides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds show 2 more
- Substituents
- 2-iodophenol / 4-iodophenol / 8-hydroxyquinoline / Aromatic heteropolycyclic compound / Aryl halide / Aryl iodide / Azacycle / Benzenoid / Haloquinoline / Heteroaromatic compound show 9 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- quinolines (CHEBI:5950)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 63W7IE88K8
- CAS number
- 83-73-8
- InChI Key
- UXZFQZANDVDGMM-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
- IUPAC Name
- 5,7-diiodoquinolin-8-ol
- SMILES
- OC1=C2N=CC=CC2=C(I)C=C1I
References
- General References
- Not Available
- External Links
- KEGG Drug
- D00581
- KEGG Compound
- C07636
- PubChem Compound
- 3728
- PubChem Substance
- 310265032
- ChemSpider
- 3597
- BindingDB
- 66035
- 3435
- ChEBI
- 5950
- ChEMBL
- CHEMBL86754
- ZINC
- ZINC000003830942
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Diiodohydroxyquinoline
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Gel Topical Suspension Oral 4.200 g Tablet Oral 650.000 mg Tablet Oral 210 mg Tablet Oral 650 mg Capsule Oral Tablet Oral 100 mg Cream Topical Tablet Oral Suppository Vaginal Cream Vaginal Suspension Oral 2.000 g Tablet Vaginal 100 mg Tablet Vaginal Tablet - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0815 mg/mL ALOGPS logP 3.93 ALOGPS logP 3.69 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 7.39 Chemaxon pKa (Strongest Basic) 3.34 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 33.12 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 68.69 m3·mol-1 Chemaxon Polarizability 25.9 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0009000000-d9a3c8ef5d196bfa37cb Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0002-0009000000-a75de789faa77bc33832 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0002-0009000000-653f4e8871e93e9a5d4a Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0002-0009000000-349ea7c70ba087f0b1be Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-00kf-0079000000-b5679d3c690306dd85f3 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-1019000000-1999e3f885585693a2c5 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 135.9323605 predictedDarkChem Lite v0.1.0 [M-H]- 151.9337 predictedDeepCCS 1.0 (2019) [M+H]+ 136.3583605 predictedDarkChem Lite v0.1.0 [M+H]+ 154.29169 predictedDeepCCS 1.0 (2019) [M+Na]+ 136.1686605 predictedDarkChem Lite v0.1.0 [M+Na]+ 160.90657 predictedDeepCCS 1.0 (2019)
Drug created at September 22, 2015 17:14 / Updated at February 21, 2021 18:52