Nucleoside diphosphate kinase B

BE0003281ProteinHumansNME2

Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:11121025, PubMed:16313181, PubMed:1851158,... It is acted on by 6 drugs in DrugBank.

Gene name
NME2
UniProtKB entry
P22392Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
152 residues · 17,298 Da
Also known as
2.7.4.6 · C-myc purine-binding transcription factor PUF · Histidine protein kinase NDKB · NDK2 · NDP kinase B

Resolves to

Protein
UniProtP22392UniProt nameNDKB_HUMAN
Gene
HGNCHGNC:7850NCBI Gene4831GeneCardsNME2
Pharmacology
KEGGhsa:654364
Structure
PDB1NSKPDB1NUEPDB3BBB
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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4Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nucleoside diphosphate kinase B, how selective are they, and which programs against it are still in active trials?

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