Gamma-secretase subunit PEN-2

BE0003410ProteinHumansPSENEN

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12679784, PubMed:12740439, PubMed:12763021, PubMed:24941111, PubMed:30598546, PubMed:30630874). It is acted on by 13 drugs in DrugBank.

Gene name
PSENEN
UniProtKB entry
Q9NZ42Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
101 residues · 12,029 Da
Also known as
PEN2 · Presenilin enhancer protein 2

Resolves to

Protein
UniProtQ9NZ42UniProt namePEN2_HUMAN
Gene
HGNCHGNC:30100NCBI Gene55851GeneCardsPSENEN
Pharmacology
KEGGhsa:55851
Structure
PDB5A63PDB5FN2PDB5FN3
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-secretase subunit PEN-2, how selective are they, and which programs against it are still in active trials?

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