DNA damage-inducible transcript 4 protein

BE0003445ProteinHumansDDIT4

Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). It is acted on by 1 drug in DrugBank.

Gene name
DDIT4
UniProtKB entry
Q9NX09Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
232 residues · 25,370 Da
Also known as
HIF-1 responsive protein RTP801 · Protein regulated in development and DNA damage response 1 · REDD-1 · REDD1 · RTP801

Resolves to

Protein
UniProtQ9NX09UniProt nameDDIT4_HUMAN
Gene
HGNCHGNC:24944NCBI Gene54541GeneCardsDDIT4
Pharmacology
KEGGhsa:54541
Structure
PDB3LQ9PDB7MOP
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA damage-inducible transcript 4 protein, and which indications are they being tested in?

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