The DNA sequence and comparative analysis of human chromosome 10.

Article Details

Citation

Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J

The DNA sequence and comparative analysis of human chromosome 10.

Nature. 2004 May 27;429(6990):375-81.

PubMed ID
15164054 [ View in PubMed
]
Abstract

The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. Sequence annotation revealed 1,357 genes, of which 816 are protein coding, and 430 are pseudogenes. We observed widespread occurrence of overlapping coding genes (either strand) and identified 67 antisense transcripts. Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. Multispecies comparative analysis indicated that we can readily annotate the protein-coding genes with current resources. We estimate that over 95% of all coding exons were identified in this study. Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylatingQ15738Details
Prolyl 4-hydroxylase subunit alpha-1P13674Details
Synaptic vesicular amine transporterQ05940Details
Aldo-keto reductase family 1 member C1Q04828Details
Beta-1 adrenergic receptorP08588Details
Glutamate dehydrogenase 1, mitochondrialP00367Details
Arachidonate 5-lipoxygenaseP09917Details
Retinol-binding protein 3P10745Details
Cytosolic purine 5'-nucleotidaseP49902Details
Alpha-2A adrenergic receptorP08913Details
Retinol-binding protein 4P02753Details
Steroid 17-alpha-hydroxylase/17,20 lyaseP05093Details
S-adenosylmethionine synthase isoform type-1Q00266Details
Ornithine aminotransferase, mitochondrialP04181Details
Methionine-R-sulfoxide reductase B2, mitochondrialQ9Y3D2Details
Aldo-keto reductase family 1 member C4P17516Details
Threonine synthase-like 1Q8IYQ7Details
Choline O-acetyltransferaseP28329Details
Aspartate aminotransferase, cytoplasmicP17174Details
Calcium-activated potassium channel subunit alpha-1Q12791Details
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialP45954Details
Aldo-keto reductase family 1 member C3P42330Details
Aldo-keto reductase family 1 member C2P52895Details
5-hydroxytryptamine receptor 7P34969Details
Interleukin-2 receptor subunit alphaP01589Details
Neuron-specific vesicular protein calcyonQ9NYX4Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialO95169Details
Pancreatic triacylglycerol lipaseP16233Details
Fibroblast growth factor receptor 2P21802Details
Glutathione S-transferase omega-1P78417Details
Delta-1-pyrroline-5-carboxylate synthaseP54886Details
Urokinase-type plasminogen activatorP00749Details
CubilinO60494Details
Canalicular multispecific organic anion transporter 1Q92887Details
Cyclin-dependent kinase 1P06493Details
Pulmonary surfactant-associated protein DP35247Details
Hexokinase-1P19367Details
Methylated-DNA--protein-cysteine methyltransferaseP16455Details
Stromal cell-derived factor 1P48061Details
ProsaposinP07602Details
Insulin-degrading enzymeP14735Details
Protein kinase C theta typeQ04759Details
Peptidyl-prolyl cis-trans isomerase F, mitochondrialP30405Details
Caspase-7P55210Details
Kinesin-like protein KIF11P52732Details
Phytanoyl-CoA dioxygenase, peroxisomalO14832Details
Neuropilin-1O14786Details
Glutamate receptor ionotropic, delta-1Q9ULK0Details
Glutathione S-transferase omega-2Q9H4Y5Details
Voltage-dependent L-type calcium channel subunit beta-2Q08289Details
Nuclear factor NF-kappa-B p100 subunitQ00653Details
Proto-oncogene tyrosine-protein kinase receptor RetP07949Details
Neuropeptide Y receptor type 4P50391Details
NAD-dependent protein deacetylase sirtuin-1Q96EB6Details
Voltage-dependent anion-selective channel protein 2P45880Details
Hypoxia-inducible factor 1-alpha inhibitorQ9NWT6Details
tRNA (cytosine(38)-C(5))-methyltransferaseO14717Details
Cytochrome P450 2C9P11712Details
Cytochrome P450 2C8P10632Details
Pleckstrin homology domain-containing family A member 1Q9HB21Details
Free fatty acid receptor 4Q5NUL3Details
DNA damage-inducible transcript 4 proteinQ9NX09Details
Cytochrome P450 26A1O43174Details
Cytochrome P450 2E1P05181Details
Cytochrome P450 2C19P33261Details
Adenosine kinaseP55263Details
Receptor-type tyrosine-protein phosphatase epsilonP23469Details
Integrin beta-1P05556Details
Cytochrome P450 2C18P33260Details
Gastric triacylglycerol lipaseP07098Details
Matrix metalloproteinase-21Q8N119Details
Glycylpeptide N-tetradecanoyltransferase 2O60551Details
Mitogen-activated protein kinase 8P45983Details
ATP synthase subunit gamma, mitochondrialP36542Details
STE20-like serine/threonine-protein kinaseQ9H2G2Details
Isopentenyl-diphosphate Delta-isomerase 1Q13907Details
Calcium/calmodulin-dependent protein kinase type 1DQ8IU85Details
Calcium/calmodulin-dependent protein kinase type II subunit gammaQ13555Details
VimentinP08670Details
Tolloid-like protein 2Q9Y6L7Details
Pulmonary surfactant-associated protein A1Q8IWL2Details
DNA nucleotidylexotransferaseP04053Details
Enoyl-CoA hydratase, mitochondrialP30084Details
Catechol O-methyltransferase domain-containing protein 1Q86VU5Details
ADP-ribosylation factor-like protein 3P36405Details
Inhibitor of nuclear factor kappa-B kinase subunit alphaO15111Details
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'P51160Details
Hyaluronan-binding protein 2Q14520Details
Arsenite methyltransferaseQ9HBK9Details
Actin, aortic smooth muscleP62736Details
Nucleolar and coiled-body phosphoprotein 1Q14978Details
Protein O-GlcNAcaseO60502Details
Metal transporter CNNM2Q9H8M5Details
Polycystic kidney disease 2-like 1 proteinQ9P0L9Details
Heterogeneous nuclear ribonucleoprotein FP52597Details
Cytochrome P450 26C1Q6V0L0Details
Inter-alpha-trypsin inhibitor heavy chain H2P19823Details
Macrophage mannose receptor 1P22897Details
Myosin-IIIaQ8NEV4Details
1,5-anhydro-D-fructose reductaseQ96JD6Details
Zinc transporter ZIP12Q504Y0Details
Equilibrative nucleoside transporter 3Q9BZD2Details