The DNA sequence and comparative analysis of human chromosome 10.
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Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
The DNA sequence and comparative analysis of human chromosome 10.
Nature. 2004 May 27;429(6990):375-81.
- PubMed ID
- 15164054 [ View in PubMed]
- Abstract
The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. Sequence annotation revealed 1,357 genes, of which 816 are protein coding, and 430 are pseudogenes. We observed widespread occurrence of overlapping coding genes (either strand) and identified 67 antisense transcripts. Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. Multispecies comparative analysis indicated that we can readily annotate the protein-coding genes with current resources. We estimate that over 95% of all coding exons were identified in this study. Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating Q15738 Details Prolyl 4-hydroxylase subunit alpha-1 P13674 Details Synaptic vesicular amine transporter Q05940 Details Aldo-keto reductase family 1 member C1 Q04828 Details Beta-1 adrenergic receptor P08588 Details Glutamate dehydrogenase 1, mitochondrial P00367 Details Arachidonate 5-lipoxygenase P09917 Details Retinol-binding protein 3 P10745 Details Cytosolic purine 5'-nucleotidase P49902 Details Alpha-2A adrenergic receptor P08913 Details Retinol-binding protein 4 P02753 Details Steroid 17-alpha-hydroxylase/17,20 lyase P05093 Details S-adenosylmethionine synthase isoform type-1 Q00266 Details Ornithine aminotransferase, mitochondrial P04181 Details Methionine-R-sulfoxide reductase B2, mitochondrial Q9Y3D2 Details Aldo-keto reductase family 1 member C4 P17516 Details Threonine synthase-like 1 Q8IYQ7 Details Choline O-acetyltransferase P28329 Details Aspartate aminotransferase, cytoplasmic P17174 Details Calcium-activated potassium channel subunit alpha-1 Q12791 Details Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial P45954 Details Aldo-keto reductase family 1 member C3 P42330 Details Aldo-keto reductase family 1 member C2 P52895 Details 5-hydroxytryptamine receptor 7 P34969 Details Interleukin-2 receptor subunit alpha P01589 Details Neuron-specific vesicular protein calcyon Q9NYX4 Details NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial O95169 Details Pancreatic triacylglycerol lipase P16233 Details Fibroblast growth factor receptor 2 P21802 Details Glutathione S-transferase omega-1 P78417 Details Delta-1-pyrroline-5-carboxylate synthase P54886 Details Urokinase-type plasminogen activator P00749 Details Cubilin O60494 Details Canalicular multispecific organic anion transporter 1 Q92887 Details Cyclin-dependent kinase 1 P06493 Details Pulmonary surfactant-associated protein D P35247 Details Hexokinase-1 P19367 Details Methylated-DNA--protein-cysteine methyltransferase P16455 Details Stromal cell-derived factor 1 P48061 Details Prosaposin P07602 Details Insulin-degrading enzyme P14735 Details Protein kinase C theta type Q04759 Details Peptidyl-prolyl cis-trans isomerase F, mitochondrial P30405 Details Caspase-7 P55210 Details Kinesin-like protein KIF11 P52732 Details Phytanoyl-CoA dioxygenase, peroxisomal O14832 Details Neuropilin-1 O14786 Details Glutamate receptor ionotropic, delta-1 Q9ULK0 Details Glutathione S-transferase omega-2 Q9H4Y5 Details Voltage-dependent L-type calcium channel subunit beta-2 Q08289 Details Nuclear factor NF-kappa-B p100 subunit Q00653 Details Proto-oncogene tyrosine-protein kinase receptor Ret P07949 Details Neuropeptide Y receptor type 4 P50391 Details NAD-dependent protein deacetylase sirtuin-1 Q96EB6 Details Voltage-dependent anion-selective channel protein 2 P45880 Details Hypoxia-inducible factor 1-alpha inhibitor Q9NWT6 Details tRNA (cytosine(38)-C(5))-methyltransferase O14717 Details Cytochrome P450 2C9 P11712 Details Cytochrome P450 2C8 P10632 Details Pleckstrin homology domain-containing family A member 1 Q9HB21 Details Free fatty acid receptor 4 Q5NUL3 Details DNA damage-inducible transcript 4 protein Q9NX09 Details Cytochrome P450 26A1 O43174 Details Cytochrome P450 2E1 P05181 Details Cytochrome P450 2C19 P33261 Details Adenosine kinase P55263 Details Receptor-type tyrosine-protein phosphatase epsilon P23469 Details Integrin beta-1 P05556 Details Cytochrome P450 2C18 P33260 Details Gastric triacylglycerol lipase P07098 Details Matrix metalloproteinase-21 Q8N119 Details Glycylpeptide N-tetradecanoyltransferase 2 O60551 Details Mitogen-activated protein kinase 8 P45983 Details ATP synthase subunit gamma, mitochondrial P36542 Details STE20-like serine/threonine-protein kinase Q9H2G2 Details Isopentenyl-diphosphate Delta-isomerase 1 Q13907 Details Calcium/calmodulin-dependent protein kinase type 1D Q8IU85 Details Calcium/calmodulin-dependent protein kinase type II subunit gamma Q13555 Details Vimentin P08670 Details Tolloid-like protein 2 Q9Y6L7 Details Pulmonary surfactant-associated protein A1 Q8IWL2 Details DNA nucleotidylexotransferase P04053 Details Enoyl-CoA hydratase, mitochondrial P30084 Details Catechol O-methyltransferase domain-containing protein 1 Q86VU5 Details ADP-ribosylation factor-like protein 3 P36405 Details Inhibitor of nuclear factor kappa-B kinase subunit alpha O15111 Details Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' P51160 Details Hyaluronan-binding protein 2 Q14520 Details Arsenite methyltransferase Q9HBK9 Details Actin, aortic smooth muscle P62736 Details Nucleolar and coiled-body phosphoprotein 1 Q14978 Details Protein O-GlcNAcase O60502 Details Metal transporter CNNM2 Q9H8M5 Details Polycystic kidney disease 2-like 1 protein Q9P0L9 Details Heterogeneous nuclear ribonucleoprotein F P52597 Details Cytochrome P450 26C1 Q6V0L0 Details Inter-alpha-trypsin inhibitor heavy chain H2 P19823 Details Macrophage mannose receptor 1 P22897 Details Myosin-IIIa Q8NEV4 Details 1,5-anhydro-D-fructose reductase Q96JD6 Details Zinc transporter ZIP12 Q504Y0 Details Equilibrative nucleoside transporter 3 Q9BZD2 Details Proliferation marker protein Ki-67 P46013 Details