Caspase-8

BE0003460ProteinHumansCASP8

Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580,... It is acted on by 8 drugs in DrugBank.

Gene name
CASP8
UniProtKB entry
Q14790Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
479 residues · 55,391 Da
Also known as
3.4.22.61 · Apoptotic cysteine protease · Apoptotic protease Mch-5 · CAP4 · CASP-8

Resolves to

Protein
UniProtQ14790UniProt nameCASP8_HUMAN
Gene
HGNCHGNC:1509NCBI Gene841GeneCardsCASP8
Pharmacology
IUPHAR/GtoPdb1624KEGGhsa:841
Structure
PDB1F9EPDB1I4EPDB1QDU
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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42GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Caspase-8, and which indications are they being tested in?

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