Nivocasan

DB12720InvestigationalSmall molecule

Nivocasan has been used in trials studying the treatment of HCV Infection and Nonalcoholic Steatohepatitis.

Mechanism: Pharmacologically active on Caspase-1, Caspase-8, and Caspase-9
Curator reviewed
Formula / weight: C₂₁H₂₂FN₃O₅ · 415.421 g/mol (avg)
Code names: GS-9450 · LB84451

Resolves to

Compound

Structure

InChIKeyVYFGDLGHHBUDTQ-ZLGUVYLKSA-NSMILESCC(C)[C@]1(CC(=NO1)C1=NC=CC2=CC=CC=C12)C(=O)N[C@H]1CC(=O)O[C@]1(O)CF

Targets

What you can answer from here — as of June 15, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

3Clinical trialsPhase, status and sponsor resolved per trial

7+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nivocasan, and which of those have an active Phase 3 trial?

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