The DNA sequence and analysis of human chromosome 14.

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Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J

The DNA sequence and analysis of human chromosome 14.

Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1.

PubMed ID
12508121 [ View in PubMed
]
Abstract

Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5' end.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Glycogen phosphorylase, liver formP06737Details
Dehydrogenase/reductase SDR family member 4Q9BTZ2Details
Mitochondrial basic amino acids transporterQ8N8R3Details
Tryptophan--tRNA ligase, cytoplasmicP23381Details
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialQ02252Details
Prostaglandin D2 receptorQ13258Details
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1O75438Details
Protein amnionlessQ9BXJ7Details
CalmodulinP0DP23Details
RAC-alpha serine/threonine-protein kinaseP31749Details
Thyrotropin receptorP16473Details
C-1-tetrahydrofolate synthase, cytoplasmicP11586Details
Serine palmitoyltransferase 2O15270Details
Retinol dehydrogenase 12Q96NR8Details
Large neutral amino acids transporter small subunit 2Q9UHI5Details
Estrogen receptor betaQ92731Details
Glutathione peroxidase 2P18283Details
Maleylacetoacetate isomeraseO43708Details
Eosinophil cationic proteinP12724Details
ChymaseP23946Details
Heat shock protein HSP 90-alphaP07900Details
Proto-oncogene c-FosP01100Details
Galectin-3P17931Details
Plasma serine protease inhibitorP05154Details
Protein-glutamine gamma-glutamyltransferase KP22735Details
Retinol dehydrogenase 11Q8TC12Details
Trans-3-hydroxy-L-proline dehydrataseQ96EM0Details
Proteasome subunit beta type-5P28074Details
Protein farnesyltransferase subunit betaP49356Details
Hypoxia-inducible factor 1-alphaQ16665Details
DNA-(apurinic or apyrimidinic site) lyaseP27695Details
Placenta growth factorP49763Details
Bcl-2-like protein 2Q92843Details
NF-kappa-B inhibitor alphaP25963Details
Leukotriene B4 receptor 2Q9NPC1Details
DNA polymerase epsilon subunit 2P56282Details
Matrix metalloproteinase-14P50281Details
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformQ13362Details
Ig gamma-2 chain C regionP01859Details
Proteasome subunit alpha type-6P60900Details
Putative dehydrogenase/reductase SDR family member 4-like 1P0CG22Details
Ig heavy chain V-III region 23P01764Details
Immunoglobulin heavy variable 1-2P23083Details
Immunoglobulin heavy variable 3-30P01768Details
Transforming growth factor beta-3P10600Details
Ig alpha-2 chain C regionP01877Details
Jun dimerization protein 2Q8WYK2Details
Steroid hormone receptor ERR2O95718Details
Ig gamma-4 chain C regionP01861Details
C-type lectin domain family 14 member AQ86T13Details
Mitochondrial 2-oxodicarboxylate carrierQ9BQT8Details
Alpha-actinin-1P12814Details
Proteasome activator complex subunit 1Q06323Details
Thyroxine 5-deiodinaseP55073Details
Cyclin-dependent kinase-like 1Q00532Details
Mitogen-activated protein kinase kinase kinase kinase 5Q9Y4K4Details
MAP/microtubule affinity-regulating kinase 3P27448Details
Serine/threonine-protein kinase Nek9Q8TD19Details
Serine/threonine-protein kinase D1Q15139Details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialQ16822Details
60 kDa lysophospholipaseQ86U10Details
Potassium voltage-gated channel subfamily H member 5Q8NCM2Details
Type II iodothyronine deiodinaseQ92813Details
Ectonucleoside triphosphate diphosphohydrolase 5O75356Details
Thiamine-triphosphataseQ9BU02Details
Zinc transporter ZIP2Q9NP94Details
Zinc transporter ZIP9Q9NUM3Details
Immunoglobulin heavy constant gamma 3P01860Details
Immunoglobulin heavy constant epsilonP01854Details
Adenylate cyclase type 4Q8NFM4Details