Histone deacetylase 4

BE0003523ProteinHumansHDAC4

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is acted on by 9 drugs in DrugBank.

Gene name
HDAC4
UniProtKB entry
P56524Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,084 residues · 119,039 Da
Also known as
3.5.1.98 · HD4 · KIAA0288

Resolves to

Protein
UniProtP56524UniProt nameHDAC4_HUMAN
Gene
HGNCHGNC:14063NCBI Gene9759GeneCardsHDAC4
Pharmacology
IUPHAR/GtoPdb2659KEGGhsa:9759
Structure
PDB2H8NPDB2O94PDB2VQJ
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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18GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Histone deacetylase 4, how selective are they, and which programs against it are still in active trials?

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