Integrin alpha-V

BE0003576ProteinHumansITGAV

The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. It is acted on by 23 drugs in DrugBank.

Gene name
ITGAV
UniProtKB entry
P06756Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,048 residues · 116,037 Da
Also known as
MSK8 · Vitronectin receptor · Vitronectin receptor subunit alpha · VNRA · VTNR

Resolves to

Protein
UniProtP06756UniProt nameITAV_HUMAN
Gene
HGNCHGNC:6150NCBI Gene3685GenBank340307GeneCardsITGAV
Pharmacology
IUPHAR/GtoPdb2453KEGGhsa:3685
Structure
PDB1JV2PDB1L5GPDB1M1X
Drugs

What you can answer from here — as of September 07, 2019

23DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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47GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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79+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Integrin alpha-V, how selective are they, and which programs against it are still in active trials?

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