Arylamine N-acetyltransferase 1

BE0003608ProteinHumansNAT1

Xenobiotic-metabolizing enzyme that catalyzes both N-acetylation (usually detoxification) and O-acetylation (usually bioactivation) of a wide range of species-specific substrates including hydrazines, aromatic amine drugs and aromatic amine carcinogens (Probable) (PubMed:9168895). It is acted on by 6 drugs in DrugBank.

Gene name
NAT1
UniProtKB entry
P18440Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
290 residues · 33,898 Da
Also known as
2.3.1.5 · AAC1 · Aromatic-hydroxylamine O-acetyltransferase NAT1 · Arylamide acetylase 1 · Monomorphic arylamine N-acetyltransferase

Resolves to

Protein
UniProtP18440UniProt nameARY1_HUMAN
Gene
HGNCHGNC:7645NCBI Gene9GenBank219414GeneCardsNAT1
Pharmacology
KEGGhsa:9
Structure
PDB2IJAPDB2PQT
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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6Metabolic reactionsDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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27+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Arylamine N-acetyltransferase 1, how selective are they, and which programs against it are still in active trials?

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