Solute carrier organic anion transporter family member 4C1

BE0003653ProteinHumansSLCO4C1

Mediates the transport of organic anions such as steroids (estrone 3-sulfate, chenodeoxycholate, glycocholate) and thyroid hormones (3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4)), in the kidney (PubMed:14993604, PubMed:19129463, PubMed:20610891). It is acted on by 10 drugs in DrugBank.

Gene name
SLCO4C1
UniProtKB entry
Q6ZQN7Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
724 residues · 78,948 Da
Also known as
OATP-H · OATP-M1 · OATP4C1 · OATPX · Organic anion transporter M1

Resolves to

Protein
UniProtQ6ZQN7UniProt nameSO4C1_HUMAN
Gene
HGNCHGNC:23612NCBI Gene353189GenBank33308060GeneCardsSLCO4C1
Pharmacology
KEGGhsa:353189
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier organic anion transporter family member 4C1, how selective are they, and which programs against it are still in active trials?

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