D-alanyl-D-alanine carboxypeptidase DacC

BE0003685ProteinEscherichia coli (strain K12)dacC

Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. It is acted on by 7 drugs in DrugBank.

Gene name
dacC
UniProtKB entry
P08506Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
400 residues · 43,609 Da
Also known as
3.4.16.4 · DD-carboxypeptidase · PBP-6 · Penicillin-binding protein 6

Resolves to

Protein
UniProtP08506UniProt nameDACC_ECOLI
Gene
NCBI Gene945455GenBank41218
Pharmacology
KEGGecj:JW0823
Structure
PDB3IT9PDB3ITAPDB3ITB
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on D-alanyl-D-alanine carboxypeptidase DacC, how selective are they, and which programs against it are still in active trials?

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