MIO-dependent tyrosine 2,3-aminomutase

BE0003755ProteinStreptomyces globisporus

Involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. It is acted on by 1 drug in DrugBank.

UniProtKB entry
Q8GMG0Swiss-Prot
Cellular location
Cytoplasm (By similarity)
Residues / weight
539 residues · 58,138 Da
Also known as
5.4.3.6 · Tyrosine ammonia-lyase

Resolves to

Protein
UniProtQ8GMG0UniProt nameTAM_STRGL
Gene
GenBank24575077
Structure
PDB2OHYPDB2QVEPDB2RJR
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on MIO-dependent tyrosine 2,3-aminomutase, and which indications are they being tested in?

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