cAMP-dependent protein kinase catalytic subunit alpha

BE0003761ProteinHumansPRKACA

Phosphorylates a large number of substrates in the cytoplasm and the nucleus (PubMed:15642694, PubMed:15905176, PubMed:16387847, PubMed:17333334, PubMed:17565987, PubMed:17693412, PubMed:18836454, PubMed:19949837, PubMed:20356841, PubMed:21085490, PubMed:21514275, PubMed:21812984, PubMed:21852232, PubMed:31112131, PubMed:41652173). It is acted on by 43 drugs in DrugBank.

Gene name
PRKACA
UniProtKB entry
P17612Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
351 residues · 40,589 Da
Also known as
2.7.11.11 · PKA C-alpha · PKACA

Resolves to

Protein
UniProtP17612UniProt nameKAPCA_HUMAN
Gene
HGNCHGNC:9380NCBI Gene5566GenBank35479GeneCardsPRKACA
Pharmacology
IUPHAR/GtoPdb1476KEGGhsa:5566
Structure
PDB2GU8PDB3AGLPDB3AGM
Drugs

What you can answer from here — as of September 07, 2019

43DrugsApproved to experimental, with action, bond type and pharmacological action
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33GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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87+ReferencesStructured and connected to the statements they support
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Which approved drugs act on cAMP-dependent protein kinase catalytic subunit alpha, how selective are they, and which programs against it are still in active trials?

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