Neutral ceramidase

BE0003763ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Catalyzes the cleavage of the N-acyl linkage of the ceramides (Cers) to yield sphingosine (Sph) and free fatty acid at an optimal pH of 8-9. It is acted on by 1 drug in DrugBank.

UniProtKB entry
Q9I596Swiss-Prot
Cellular location
Secreted
Residues / weight
670 residues · 73,372 Da
Also known as
3.5.1.23 · Acylsphingosine deacylase · N-acylsphingosine amidohydrolase · N-CDase

Resolves to

Protein
UniProtQ9I596UniProt nameNCASE_PSEAE
Gene
NCBI Gene880698GenBank6594292
Pharmacology
KEGGpae:PA0845
Structure
PDB2ZWSPDB2ZXC
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Neutral ceramidase, and which indications are they being tested in?

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