Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Article Details
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Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Nature. 2000 Aug 31;406(6799):959-64.
- PubMed ID
- 10984043 [ View in PubMed]
- Abstract
Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Delta-aminolevulinic acid dehydratase Q59643 Details Ferripyoverdine receptor P48632 Details Chloramphenicol acetyltransferase P26841 Details Azurin P00282 Details Phosphomannomutase/phosphoglucomutase P26276 Details Aliphatic amidase expression-regulating protein P27017 Details Peptide deformylase Q9I7A8 Details Arylsulfatase P51691 Details Elastase P14756 Details p-hydroxybenzoate hydroxylase P20586 Details Nitrite reductase P24474 Details Multidrug resistance protein MexA P52477 Details Alanine racemase, catabolic Q9HTQ2 Details GDP-mannose 6-dehydrogenase P11759 Details Exotoxin A P11439 Details Phosphoheptose isomerase Q9HVZ0 Details Ribonuclease PH P50597 Details Acetylglutamate kinase Q9HTN2 Details dTDP-4-dehydrorhamnose 3,5-epimerase Q9HU21 Details Arginine N-succinyltransferase subunit alpha P80357 Details Quinoprotein ethanol dehydrogenase Q9Z4J7 Details Cytochrome c551 peroxidase P14532 Details GDP-mannose 4,6-dehydratase Q51366 Details Organic hydroperoxide resistance protein Q9HZZ3 Details Arginine deiminase P13981 Details Penicillin-binding protein 1A Q07806 Details Neutral ceramidase Q9I596 Details Uncharacterized protein PA1000 P20581 Details Porin P P05695 Details Porin D P32722 Details Vanillate porin OpdK Q9HUR5 Details Probable outer membrane protein Q9HVJ6 Details Esterase EstA O33407 Details Lipid A deacylase PagL Q9HVD1 Details Acyl-homoserine lactone acylase PvdQ Q9I194 Details UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase P47205 Details Fe(3+)-pyochelin receptor P42512 Details FMN-dependent NADH-azoreductase 1 Q9I5F3 Details Transcriptional activator protein LasR P25084 Details D-alanyl-D-alanine endopeptidase P72161 Details Multidrug resistance protein MexB P52002 Details Outer membrane protein OprM Q51487 Details DNA gyrase subunit A P48372 Details