Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Article Details


Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.

Nature. 2000 Aug 31;406(6799):959-64.

PubMed ID
10984043 [ View in PubMed

Pseudomonas aeruginosa is a ubiquitous environmental bacterium that is one of the top three causes of opportunistic human infections. A major factor in its prominence as a pathogen is its intrinsic resistance to antibiotics and disinfectants. Here we report the complete sequence of P. aeruginosa strain PAO1. At 6.3 million base pairs, this is the largest bacterial genome sequenced, and the sequence provides insights into the basis of the versatility and intrinsic drug resistance of P. aeruginosa. Consistent with its larger genome size and environmental adaptability, P. aeruginosa contains the highest proportion of regulatory genes observed for a bacterial genome and a large number of genes involved in the catabolism, transport and efflux of organic compounds as well as four potential chemotaxis systems. We propose that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.

DrugBank Data that Cites this Article

NameUniProt ID
Delta-aminolevulinic acid dehydrataseQ59643Details
Ferripyoverdine receptorP48632Details
Chloramphenicol acetyltransferaseP26841Details
Aliphatic amidase expression-regulating proteinP27017Details
Peptide deformylaseQ9I7A8Details
p-hydroxybenzoate hydroxylaseP20586Details
Nitrite reductaseP24474Details
Multidrug resistance protein MexAP52477Details
Alanine racemase, catabolicQ9HTQ2Details
GDP-mannose 6-dehydrogenaseP11759Details
Exotoxin AP11439Details
Phosphoheptose isomeraseQ9HVZ0Details
Ribonuclease PHP50597Details
Acetylglutamate kinaseQ9HTN2Details
dTDP-4-dehydrorhamnose 3,5-epimeraseQ9HU21Details
Arginine N-succinyltransferase subunit alphaP80357Details
Phenazine biosynthesis protein PhzDQ7DC80Details
Quinoprotein ethanol dehydrogenaseQ9Z4J7Details
Cytochrome c551 peroxidaseP14532Details
GDP-mannose 4,6-dehydrataseQ51366Details
Organic hydroperoxide resistance proteinQ9HZZ3Details
Arginine deiminaseP13981Details
Penicillin-binding protein 1AQ07806Details
Neutral ceramidaseQ9I596Details
Uncharacterized protein PA1000P20581Details
Porin PP05695Details
Porin DP32722Details
Vanillate porin OpdKQ9HUR5Details
Probable outer membrane proteinQ9HVJ6Details
Esterase EstAO33407Details
Lipid A deacylase PagLQ9HVD1Details
Acyl-homoserine lactone acylase PvdQQ9I194Details
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylaseP47205Details
Fe(3+)-pyochelin receptorP42512Details
FMN-dependent NADH-azoreductase 1Q9I5F3Details
Transcriptional activator protein LasRP25084Details
D-alanyl-D-alanine endopeptidaseP72161Details
Multidrug resistance protein MexBP52002Details
Outer membrane protein OprMQ51487Details
DNA gyrase subunit AP48372Details