Immunoglobulin kappa variable 2-30

Details

Name
Immunoglobulin kappa variable 2-30
Kind
protein
Synonyms
  • Ig kappa chain V-II region RPMI 6410
Gene Name
IGKV2-30
UniProtKB Entry
P06310Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0064679|Immunoglobulin kappa variable 2-30
MRLPAQLLGLLMLWVPGSSGDVVMTQSPLSLPVTLGQPASISCRSSQSLVYSDGNTYLNW
FQQRPGQSPRRLIYKVSNRDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQGTHWP
Number of residues
120
Molecular Weight
13184.875
Theoretical pI
9.53
GO Classification
Processes
adaptive immune response
Components
extracellular space / immunoglobulin complex
General Function
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)
Specific Function
antigen binding
Pfam Domain Function
Not Available
Signal Regions
1-20
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP06310
UniProtKB Entry NameKV230_HUMAN
GenBank Protein ID296655
GenBank Gene IDZ00020
GeneCard IDIGKV2-30
HGNC IDHGNC:5785
General References
  1. Klobeck HG, Meindl A, Combriato G, Solomon A, Zachau HG: Human immunoglobulin kappa light chain genes of subgroups II and III. Nucleic Acids Res. 1985 Sep 25;13(18):6499-513. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
FluoresceinapprovednotargetotherDetails
EtiocholanedioneexperimentalunknowntargetDetails