Triosephosphate isomerase

BE0003844ProteinHumansTPI1

Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. It is acted on by 17 drugs in DrugBank.

Gene name
TPI1
UniProtKB entry
P60174Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
249 residues · 26,669 Da
Also known as
5.3.1.1 · Methylglyoxal synthase · TIM · TPI · Triose-phosphate isomerase

Resolves to

Protein
UniProtP60174UniProt nameTPIS_HUMAN
Gene
HGNCHGNC:12009NCBI Gene7167GenBank339841GeneCardsTPI1
Pharmacology
KEGGhsa:7167
Structure
PDB1HTIPDB1KLGPDB1KLU
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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53+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Triosephosphate isomerase, how selective are they, and which programs against it are still in active trials?

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