Esterase EstA

BE0003982ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)estA

Esterase whose enzymatic activity is required for rhamnolipid production, all kinds of cell motility (swimming, swarming, and twitching), and biofilm formation; the exact role of EstA in these processes is unclear. It is acted on by 1 drug in DrugBank.

Gene name
estA
UniProtKB entry
O33407Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
646 residues · 69,608 Da
Also known as
3.1.1.1 · Autotransporter esterase EstA · papA

Resolves to

Protein
UniProtO33407UniProt nameESTA_PSEAE
Gene
NCBI Gene878826GenBank2218156
Pharmacology
KEGGpae:PA5112
Structure
PDB3KVN
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Esterase EstA, and which indications are they being tested in?

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