5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

BE0004031ProteinEscherichia coli O157:H7mtnN

Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. It is acted on by 1 drug in DrugBank.

Gene name
mtnN
UniProtKB entry
P0AF14Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
232 residues · 24,354 Da
Also known as
3.2.2.9 · 5'-deoxyadenosine nucleosidase · 5'-methylthioadenosine nucleosidase · AdoHcy nucleosidase · dAdo nucleosidase

Resolves to

Protein
UniProtP0AF14UniProt nameMTNN_ECO57
Gene
NCBI Gene913817GenBank12512676
Pharmacology
KEGGece:Z0170
Structure
PDB3DF9
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, and which indications are they being tested in?

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