2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

BE0004106ProteinEscherichia coli (strain K12)ispF

Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. It is acted on by 1 drug in DrugBank.

Gene name
ispF
UniProtKB entry
P62617Swiss-Prot
Residues / weight
159 residues · 16,897 Da
Also known as
4.6.1.12 · MECDP-synthase · mecS · ygbB

Resolves to

Protein
UniProtP62617UniProt nameISPF_ECOLI
Gene
NCBI Gene945057GenBank433711
Pharmacology
KEGGecj:JW2716
Structure
PDB1GX1PDB1H47PDB1H48
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, and which indications are they being tested in?

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