Type 3 secretion system pilotin

BE0004113ProteinShigella flexnerimxiM

Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:10085046, PubMed:11717255). It is acted on by 1 drug in DrugBank.

Gene name
mxiM
UniProtKB entry
P0A1X2Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
142 residues · 15,852 Da
Also known as
Lipoprotein MxiM · MxiD pilot · sctG · Secretin pilot protein

Resolves to

Protein
UniProtP0A1X2UniProt nameSCTG_SHIFL
Gene
NCBI Gene1238028GenBank152770
Pharmacology
KEGGsfl:CP0143
Structure
PDB1Y9LPDB1Y9TPDB2JW1
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Type 3 secretion system pilotin, and which indications are they being tested in?

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