Beta-hexosaminidase
Details
- Name
- Beta-hexosaminidase
- Kind
- protein
- Synonyms
- 3.2.1.52
- Beta-N-acetylhexosaminidase
- N-acetyl-beta-glucosaminidase
- N-acetylglucosaminidase
- ORF1
- ybbD
- yzbA
- Gene Name
- nagZ
- UniProtKB Entry
- P40406Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0012986|Beta-hexosaminidase MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSLDEKLGQMLMPDFRNWQ KEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQTVQLTDDYQKASPKIPLML SIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSIIGKELSALGINTDFSPVVDIN NNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIASALKHFPGHGDTDVDSHYGLPLV SHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAFDDTTYKSKLDGSDILVPATLSKKV MTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEAVVMAVKAGVDIALMPASVTSLKEEQK FARVIQALKEAVKNGDIPEQQINNSVERIISLKIKRGMYPARNSDSTKEKIAKAKKIVGS KQHLKAEKKLAEKAVTVLKNEQHTLPFKPKKGSRILIVAPYEEQTASIEQTIHDLIKRKK IKPVSLSKMNFASQVFKTEHEKQVKEADYIITGSYVVKNDPVVNDGVIDDTISDSSKWAT VFPRAVMKAALQHNKPFVLMSLRNPYDAANFEEAKALIAVYGFKGYANGRYLQPNIPAGV MAIFGQAKPKGTLPVDIPSVTKPGNTLYPLGYGLNIKTGRPL
- Number of residues
- 642
- Molecular Weight
- 70579.905
- Theoretical pI
- 9.94
- GO Classification
- Functionsbeta-N-acetylhexosaminidase activityProcessescarbohydrate metabolic process / cell wall organization / peptidoglycan biosynthetic process / peptidoglycan turnover / regulation of cell shapeComponentscell wall / extracellular region / plasma membrane
- General Function
- Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Cleaves muropeptides, but not peptidoglycan.
- Specific Function
- beta-N-acetylhexosaminidase activity
- Pfam Domain Function
- Signal Regions
- 1-16
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012987|Beta-hexosaminidase (nagZ) ATGAGACCTGTCTTTCCGCTTATCCTTTCAGCCGTTCTCTTTCTTTCATGCTTTTTCGGG GCCAGACAGACAGAAGCCTCTGCATCCAAACGTGCAATCGATGCCAATCAGATTGTCAAT CGTATGTCGTTAGATGAAAAACTCGGCCAGATGCTGATGCCTGATTTTAGAAATTGGCAA AAGGAAGGCGAGTCCTCTCCGCAAGCCCTTACAAAAATGAATGATGAAGTCGCCAGCCTC GTCAAGAAATATCAATTCGGAGGCATCATCCTTTTTGCAGAAAATGTAAAAACAACAAAA CAAACTGTCCAACTGACAGACGATTACCAAAAGGCAAGTCCAAAAATCCCGCTCATGCTG AGTATTGATCAGGAAGGCGGCATTGTAACGAGGTTAGGGGAGGGCACTAATTTCCCAGGG AATATGGCGCTGGGCGCAGCCAGAAGCAGAATCAATGCGTATCAGACCGGCAGCATCATC GGAAAAGAGCTCTCTGCCTTAGGCATCAATACAGATTTCAGCCCTGTCGTGGACATTAAC AATAATCCTGATAATCCTGTAATCGGCGTACGGTCATTCAGCTCCAATCGAGAACTGACA TCACGCCTCGGTTTATATACGATGAAAGGGTTGCAGCGGCAGGATATCGCGTCTGCCCTC AAACATTTCCCGGGACATGGAGACACGGACGTTGACAGCCATTATGGACTGCCGCTCGTT TCCCATGGCCAAGAACGGCTTCGTGAGGTCGAGCTTTATCCTTTTCAAAAAGCAATTGAT GCTGGTGCTGATATGGTGATGACAGCCCATGTTCAGTTTCCCGCCTTTGATGACACCACT TACAAAAGCAAACTCGATGGATCGGACATTCTGGTTCCAGCTACACTTTCAAAAAAAGTG ATGACAGGTCTTCTTCGTCAGGAAATGGGCTTTAATGGGGTCATCGTTACCGATGCGCTC AATATGAAGGCAATCGCAGATCATTTCGGACAGGAAGAGGCTGTGGTCATGGCCGTAAAA GCTGGTGTCGATATTGCATTAATGCCAGCCTCAGTCACTTCATTGAAAGAAGAACAGAAA TTCGCACGTGTTATTCAAGCTTTGAAAGAAGCCGTGAAAAACGGGGATATTCCTGAACAA CAAATCAACAATTCAGTTGAAAGAATCATTTCCCTGAAAATAAAACGCGGCATGTATCCA GCGCGAAACAGCGACAGTACAAAAGAAAAAATAGCCAAAGCCAAAAAAATCGTAGGAAGC AAGCAGCACCTGAAAGCAGAGAAAAAATTAGCTGAAAAAGCAGTAACTGTATTAAAAAAT GAACAGCACACTTTGCCGTTCAAGCCTAAAAAAGGCAGCCGAATCTTAATTGTGGCACCT TACGAAGAACAAACTGCTTCAATCGAACAAACCATTCACGATCTCATCAAGCGAAAGAAA ATCAAACCCGTATCCCTCAGCAAAATGAACTTTGCCAGCCAAGTATTTAAGACCGAGCAT GAAAAACAAGTAAAAGAGGCTGATTATATCATTACCGGCTCCTATGTCGTCAAAAATGAC CCTGTCGTCAACGACGGTGTCATCGACGACACAATATCAGATTCAAGCAAATGGGCCACC GTGTTTCCGAGAGCTGTCATGAAAGCCGCACTGCAGCACAACAAACCATTTGTCTTAATG AGCCTGCGCAACCCCTATGACGCAGCCAATTTCGAAGAAGCAAAAGCACTGATTGCAGTC TATGGCTTTAAAGGATACGCAAATGGCCGTTATCTTCAACCTAATATTCCGGCCGGAGTG ATGGCGATATTCGGCCAGGCAAAACCTAAAGGCACACTTCCAGTTGACATTCCGTCAGTC ACGAAACCAGGGAACACCCTTTACCCACTTGGCTACGGATTAAATATCAAAACGGGAAGA CCGCTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P40406 UniProtKB Entry Name NAGZ_BACSU GenBank Protein ID 438455 GenBank Gene ID L19954 PDB ID(s) 3BMX, 3LK6, 3NVD, 4GYJ, 4GYK KEGG ID bsu:BSU01660 NCBI Gene ID 938881 - General References
- Quirk PG, Guffanti AA, Clejan S, Cheng J, Krulwich TA: Isolation of Tn917 insertional mutants of Bacillus subtilis that are resistant to the protonophore carbonyl cyanide m-chlorophenylhydrazone. Biochim Biophys Acta. 1994 Jun 28;1186(1-2):27-34. [Article]
- Liu H, Haga K, Yasumoto K, Ohashi Y, Yoshikawa H, Takahashi H: Sequence and analysis of a 31 kb segment of the Bacillus subtilis chromosome in the area of the rrnH and rrnG operons. Microbiology. 1997 Aug;143 ( Pt 8):2763-7. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Litzinger S, Duckworth A, Nitzsche K, Risinger C, Wittmann V, Mayer C: Muropeptide rescue in Bacillus subtilis involves sequential hydrolysis by beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase. J Bacteriol. 2010 Jun;192(12):3132-43. doi: 10.1128/JB.01256-09. Epub 2010 Apr 16. [Article]
- Litzinger S, Fischer S, Polzer P, Diederichs K, Welte W, Mayer C: Structural and kinetic analysis of Bacillus subtilis N-acetylglucosaminidase reveals a unique Asp-His dyad mechanism. J Biol Chem. 2010 Nov 12;285(46):35675-84. doi: 10.1074/jbc.M110.131037. Epub 2010 Sep 7. [Article]
- Bacik JP, Whitworth GE, Stubbs KA, Vocadlo DJ, Mark BL: Active site plasticity within the glycoside hydrolase NagZ underlies a dynamic mechanism of substrate distortion. Chem Biol. 2012 Nov 21;19(11):1471-82. doi: 10.1016/j.chembiol.2012.09.016. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Diethylene glycol diethyl ether experimental unknown target Details