Beta-hexosaminidase

BE0004285ProteinBacillus subtilis (strain 168)nagZ

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. It is acted on by 1 drug in DrugBank.

Gene name
nagZ
UniProtKB entry
P40406Swiss-Prot
Cellular location
Cell membrane
Residues / weight
642 residues · 70,580 Da
Also known as
3.2.1.52 · Beta-N-acetylhexosaminidase · N-acetyl-beta-glucosaminidase · N-acetylglucosaminidase · ORF1

Resolves to

Protein
UniProtP40406UniProt nameNAGZ_BACSU
Gene
NCBI Gene938881GenBank438455
Pharmacology
KEGGbsu:BSU01660
Structure
PDB3BMXPDB3LK6PDB3NVD
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Beta-hexosaminidase, and which indications are they being tested in?

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