Interleukin-1 receptor-associated kinase 4

BE0004344ProteinHumansIRAK4

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. It is acted on by 7 drugs in DrugBank.

Gene name
IRAK4
UniProtKB entry
Q9NWZ3Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
460 residues · 51,529 Da
Also known as
2.7.11.1 · IRAK-4 · Renal carcinoma antigen NY-REN-64

Resolves to

Protein
UniProtQ9NWZ3UniProt nameIRAK4_HUMAN
Gene
HGNCHGNC:17967NCBI Gene51135GenBank20219010GeneCardsIRAK4
Pharmacology
IUPHAR/GtoPdb2045KEGGhsa:51135
Structure
PDB2NRUPDB2NRYPDB2O8Y
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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18GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-1 receptor-associated kinase 4, how selective are they, and which programs against it are still in active trials?

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