PF-06650833
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- PF-06650833
- DrugBank Accession Number
- DB15143
- Background
PF-06650833 is under investigation in clinical trial NCT02609139 (Study to Evaluate Pharmacokinetics of A Modified Release Formulation of PF-06650833 in Healthy Subjects).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 361.373
Monoisotopic: 361.143784299 - Chemical Formula
- C18H20FN3O4
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- S3F315JJXI
- CAS number
- 1817626-54-2
- InChI Key
- JKDGKIBAOAFRPJ-ZBINZKHDSA-N
- InChI
- InChI=1S/C18H20FN3O4/c1-3-10-13(22-17(24)15(10)19)8-26-18-11-7-14(25-2)12(16(20)23)6-9(11)4-5-21-18/h4-7,10,13,15H,3,8H2,1-2H3,(H2,20,23)(H,22,24)/t10-,13+,15-/m0/s1
- IUPAC Name
- 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide
- SMILES
- CC[C@H]1[C@@H](COC2=C3C=C(OC)C(=CC3=CC=N2)C(N)=O)NC(=O)[C@H]1F
References
- General References
- Not Available
- External Links
- ChemSpider
- 58805665
- BindingDB
- 50239499
- ChEMBL
- CHEMBL4081711
- ZINC
- ZINC000526061587
- PDBe Ligand
- 8CG
- PDB Entries
- 5uiu
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Acne Inversa 1 2 Completed Treatment Rheumatoid Arthritis 2 2 Recruiting Treatment Coronavirus Disease 2019 (COVID‑19) / COVID-19 Pneumonia 1 2 Terminated Treatment Coronavirus Disease 2019 (COVID‑19) 1 1 Completed Basic Science Healthy Subjects (HS) 5 1 Completed Other Healthy Subjects (HS) 1 1 Completed Treatment Healthy Subjects (HS) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0936 mg/mL ALOGPS logP 1.75 ALOGPS logP 1.05 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 10.59 Chemaxon pKa (Strongest Basic) 2.52 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 103.54 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 91.4 m3·mol-1 Chemaxon Polarizability 35.84 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 20, 2019 14:53 / Updated at June 12, 2020 16:53