Aldo-keto reductase family 1 member B10

BE0004353ProteinHumansAKR1B10

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). It is acted on by 8 drugs in DrugBank.

Gene name
AKR1B10
UniProtKB entry
O60218Swiss-Prot
Cellular location
Lysosome
Residues / weight
316 residues · 36,019 Da
Also known as
1.1.1.300 · 1.1.1.54 · AKR1B11 · Aldose reductase-like · Aldose reductase-related protein

Resolves to

Protein
UniProtO60218UniProt nameAK1BA_HUMAN
Gene
HGNCHGNC:382NCBI Gene57016GenBank3150035GeneCardsAKR1B10
Pharmacology
KEGGhsa:57016
Structure
PDB1ZUAPDB4GA8PDB4GAB
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldo-keto reductase family 1 member B10, how selective are they, and which programs against it are still in active trials?

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