Calcium/calmodulin-dependent protein kinase type II subunit gamma

BE0004384ProteinHumansCAMK2G

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). It is acted on by 4 drugs in DrugBank.

Gene name
CAMK2G
UniProtKB entry
Q13555Swiss-Prot
Cellular location
Sarcoplasmic reticulum membrane
Residues / weight
558 residues · 62,607 Da
Also known as
2.7.11.17 · CaM kinase II subunit gamma · CAMK · CAMK-II · CaMK-II subunit gamma

Resolves to

Protein
UniProtQ13555UniProt nameKCC2G_HUMAN
Gene
HGNCHGNC:1463NCBI Gene818GenBank21707842GeneCardsCAMK2G
Pharmacology
IUPHAR/GtoPdb1557KEGGhsa:818
Structure
PDB2UX0PDB2V7O
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calcium/calmodulin-dependent protein kinase type II subunit gamma, how selective are they, and which programs against it are still in active trials?

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