Superoxide dismutase [Mn], mitochondrial

BE0004453ProteinHumansSOD2

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. It is acted on by 8 drugs in DrugBank.

Gene name
SOD2
UniProtKB entry
P04179Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
222 residues · 24,750 Da
Also known as
1.15.1.1

Resolves to

Protein
UniProtP04179UniProt nameSODM_HUMAN
Gene
HGNCHGNC:11180NCBI Gene6648GeneCardsSOD2
Pharmacology
KEGGhsa:6648
Structure
PDB1AP5PDB1AP6PDB1EM1
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Superoxide dismutase [Mn], mitochondrial, how selective are they, and which programs against it are still in active trials?

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