Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

BE0004522ProteinHumansITPR1

Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797). It is acted on by 4 drugs in DrugBank.

Gene name
ITPR1
UniProtKB entry
Q14643Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
2,758 residues · 313,926 Da
Also known as
Inositol 1,4,5 trisphosphate receptor · Inositol 1,4,5-trisphosphate receptor type 1 · INSP3R1 · IP3 receptor isoform 1 · IP3R 1

Resolves to

Protein
UniProtQ14643UniProt nameITPR1_HUMAN
Gene
HGNCHGNC:6180NCBI Gene3708GeneCardsITPR1
Pharmacology
KEGGhsa:3708
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
23GO termsFunction, process and component, as structured annotations
Sign in
5Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
26+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In